Human flightless I homolog (Drosophila) ELISA Kit | FLII elisa kit
Human Protein flightless-1 homolog, FLII ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Uniprot Description
FLI: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration. Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS). It is a contiguous gene deletion syndrome involving developmental abnormalities and mental retardation. The spectrum of clinical findings includes short stature, brachydactyly, developmental delay, dysmorphic features, sleep disturbances, and behavioral problems.
Protein type: Actin-binding; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: nucleoplasm; focal adhesion; cytoplasm; microtubule organizing center
Molecular Function: protein binding; actin binding
Biological Process: actin filament severing; regulation of transcription, DNA-dependent; muscle contraction; transcription, DNA-dependent; multicellular organismal development; actin cytoskeleton organization and biogenesis
Disease: Smith-magenis Syndrome
Research Articles on FLII
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Product Notes
The Human FLII flii (Catalog #AAA9329638) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329638 ELISA Kit recognizes Human FLII. It is sometimes possible for the material contained within the vial of "flightless I homolog (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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