Human glucocorticoid modulatory element binding protein 1 ELISA Kit | GMEB1 elisa kit
Human Glucocorticoid modulatory element-binding protein 1, GMEB1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2011]
Uniprot Description
GMEB1: Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1p35.3
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: DNA binding; metal ion binding; transcription coactivator activity; transcription factor activity
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent
Research Articles on GMEB1
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Product Notes
The Human GMEB1 gmeb1 (Catalog #AAA9328858) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328858 ELISA Kit recognizes Human GMEB1. It is sometimes possible for the material contained within the vial of "glucocorticoid modulatory element binding protein 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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