Human nanos homolog 2 (Drosophila) ELISA Kit | NANOS2 elisa kit
Human Nanos homolog 2, NANOS2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
NANOS2: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state. Belongs to the nanos family.
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: perinuclear region of cytoplasm; cytoplasm; nucleus
Molecular Function: mRNA binding; protein binding; zinc ion binding
Biological Process: multicellular organismal development; negative regulation of translation; negative regulation of meiosis; mRNA catabolic process; germ-line stem cell maintenance; spermatogenesis
Research Articles on NANOS2
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Product Notes
The Human NANOS2 nanos2 (Catalog #AAA9326983) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326983 ELISA Kit recognizes Human NANOS2. It is sometimes possible for the material contained within the vial of "nanos homolog 2 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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