Mouse Zic family member 2 (odd-paired homolog, Drosophila) ELISA Kit | ZIC2 elisa kit
Mouse Zinc finger protein ZIC 2, ZIC2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ZIC2: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. Defects in ZIC2 are a cause of holoprosencephaly type 5 (HPE5). A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Although severe facial anomalies are common in HPE, patients with ZINC2 mutations have relatively normal faces. Belongs to the GLI C2H2-type zinc-finger protein family.
Protein type: C2H2-type zinc finger protein; DNA-binding
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; nucleic acid binding; chromatin DNA binding; metal ion binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; nervous system development; central nervous system development; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; multicellular organismal development; pigmentation during development; regulation of transcription, DNA-dependent; visual perception; neural tube closure; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cell differentiation; retinal ganglion cell axon guidance
Research Articles on ZIC2
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Product Notes
The Mouse ZIC2 zic2 (Catalog #AAA9326264) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326264 ELISA Kit recognizes Mouse ZIC2. It is sometimes possible for the material contained within the vial of "Zic family member 2 (odd-paired homolog, Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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