Rat cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) ELISA Kit | CDKN2A elisa kit
Rat Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, CDKN2A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
tumor suppressor that inhibits CDK4; inactivation or loss is associated with cellular transformation; may be involved in CNS degeneration following injury [RGD, Feb 2006]
Uniprot Description
p16-INK4A: a cell-cycle regulatory protein that interacts with CDK4 and CDK6, inhibiting their ability to interact with cyclins D. Inhibits the phosphorylation of the retinoblastoma protein by CDK4 or CDK6, and entry into the S phase of the cell cycle. The p16INK4A and p14ARF proteins are encoded by CDKN2A, a known tumour suppressor gene in multiple cancers. CDKN2A is inactivated in 72% of cases of lung squamous cell carcinoma: 21% by epigenetic silencing by methylation, 18% inactivating mutation, 4% by exon 1b skipping, and 29% by homozygous deletion. Defects in CDKN2A are the cause of familial atypical multiple mole melanoma-pancreatic carcinoma syndrome, Li-Fraumeni syndrome, and the melanoma-astrocytoma syndrome. The melanoma-astrocytoma syndrome is characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma. Four alternatively spliced p16 isoforms have been reported. Two alternatively spliced isoforms of ARF have been reported.
Protein type: Cell cycle regulation; Nucleolus; Tumor suppressor
Cellular Component: nucleoplasm; nuclear body; granular component; protein complex; cytoplasm; nucleolus; nucleus
Molecular Function: cyclin-dependent protein kinase inhibitor activity; NF-kappaB binding; DNA binding; p53 binding; ubiquitin-protein ligase inhibitor activity; transcription factor binding; transcription factor activity; protein kinase binding
Biological Process: protein polyubiquitination; positive regulation of apoptosis; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; glucose homeostasis; response to organic cyclic substance; regulation of protein export from nucleus; regulation of G2/M transition of mitotic cell cycle; somatic stem cell division; cerebellum development; negative regulation of protein binding; cell cycle arrest; response to drug; negative regulation of immature T cell proliferation in the thymus; transcription, DNA-dependent; negative regulation of cyclin-dependent protein kinase activity; cell aging; response to organic nitrogen; negative regulation of cell-matrix adhesion; negative regulation of mammary gland epithelial cell proliferation; rRNA transcription; positive regulation of protein sumoylation; regulation of gene expression; inhibition of NF-kappaB transcription factor; negative regulation of ubiquitin-protein ligase activity; negative regulation of phosphorylation; negative regulation of protein kinase activity; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of transcription, DNA-dependent; rRNA processing; G1/S transition of mitotic cell cycle; epidermis development; apoptosis; positive regulation of apoptosis involved in mammary gland involution; regulation of protein stability; negative regulation of B cell proliferation; negative regulation of cell cycle; response to organic substance; negative regulation of cell proliferation; apoptotic mitochondrial changes; regulation of transcription, DNA-dependent; aging; caspase activation; protein destabilization; protein stabilization; regulation of nucleocytoplasmic transport; Ras protein signal transduction; negative regulation of cell growth; regulation of cyclin-dependent protein kinase activity
Research Articles on CDKN2A
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Product Notes
The Rat CDKN2A cdkn2a (Catalog #AAA9326035) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326035 ELISA Kit recognizes Rat CDKN2A. It is sometimes possible for the material contained within the vial of "cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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