Human calcium channel, voltage-dependent, gamma subunit 2 ELISA Kit | CACNG2 elisa kit
Human Voltage-dependent calcium channel gamma-2 subunit, CACNG2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
Uniprot Description
Stargazin: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1. Brain. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: plasma membrane; voltage-gated calcium channel complex
Molecular Function: voltage-gated calcium channel activity; ionotropic glutamate receptor binding; protein binding
Biological Process: membrane depolarization; synaptic transmission; transport; membrane hyperpolarization; transmission of nerve impulse; neuromuscular junction development
Disease: Mental Retardation, Autosomal Dominant 10
Research Articles on CACNG2
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Product Notes
The Human CACNG2 cacng2 (Catalog #AAA9325678) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325678 ELISA Kit recognizes Human CACNG2. It is sometimes possible for the material contained within the vial of "calcium channel, voltage-dependent, gamma subunit 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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