Rabbit anti-Human DLGAP4 Polyclonal Antibody | anti-DLGAP4 antibody

Rabbit Polyclonal to Human DLGAP4

Cat. Num. AAA243383

• Gene Names: DLGAP4; DAP4; DLP4; DAP-4; SAPAP4; SAPAP-4
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: DLGAP4; Polyclonal Antibody; Rabbit Polyclonal to Human DLGAP4; Anti-DLGAP4 Antibody (Internal) IHC-plus; DLP4; DAP-4; KIAA0964; PSD-95/SAP90-binding protein 4; RP5-977B1.6; SAPAP-4; SAPAP4; Human DLGAP4; anti-DLGAP4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 989

• Applicable Applications for anti-DLGAP4 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml); Usage: SAPAP4 antibody can be used for detection of SAPAP4 by Western blot at 0.5-1 ug/ml
• Target Species: Human
• Immunogen Description: A 13 amino acid peptide from near the center of human SAPAP4.
• Immunogen Type: Synthetic peptide
• Immunogen: DLGAP4 antibody was raised against a 13 amino acid peptide from near the center of human SAPAP4.
• Antigen Modification: Internal
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-DLGAP4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of DLGAP4 in SK-N-SH cell lysate with DLGAP4 antibody at 1 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 34335253
• NCBI GeneID: 22839
• NCBI Accession #: NP_055717.2
• NCBI GenBank Nucleotide #: NM_014902.5
• UniProt Accession #: Q9Y2H0; Q5QPG4; Q5T2Y4; Q5T2Y5; Q9H137; Q9H138; Q9H1L7; E1P5T5
• Molecular Weight: 49,478 Da
• NCBI Official Full Name: disks large-associated protein 4 isoform a
• NCBI Official Synonym Full Names: discs, large (Drosophila) homolog-associated protein 4
• NCBI Official Symbol: DLGAP4
• NCBI Official Synonym Symbols: DAP4; DLP4; DAP-4; SAPAP4; SAPAP-4
• NCBI Protein Information: disks large-associated protein 4; PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4
• UniProt Protein Name: Disks large-associated protein 4
• Protein Family: Disks large-associated protein
• UniProt Gene Name: DLGAP4
• UniProt Synonym Gene Names: DAP4; KIAA0964; SAPAP4; DAP-4; SAPAP-4
• UniProt Entry Name: DLGP4_HUMAN

NCBI Description

The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SAPAP4: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Belongs to the SAPAP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: membrane; synapse

Molecular Function: protein binding

Biological Process: cell-cell signaling