Mouse aurora kinase A ELISA Kit | AURKA elisa kit
Mouse Serine/threonine-protein kinase 6, AURKA ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
AurA: a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Oncoprotein; Other group; AUR family
Cellular Component: germinal vesicle; microtubule; centrosome; pronucleus; spindle pole centrosome; axon hillock; microtubule cytoskeleton; cytoskeleton; spindle microtubule; perinuclear region of cytoplasm; cytoplasm; microtubule organizing center; spindle; spindle midzone; nucleus; condensed nuclear chromosome, pericentric region
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; transferase activity, transferring phosphorus-containing groups; protein serine/threonine/tyrosine kinase activity; nucleotide binding; histone serine kinase activity; kinase activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: spindle stabilization; meiosis; mitosis; regulation of protein stability; microtubule cytoskeleton organization and biogenesis; cell cycle; protein amino acid phosphorylation; regulation of cytokinesis; mitotic centrosome separation; mitotic spindle organization and biogenesis; centrosome localization; cell projection organization and biogenesis; centrosome organization and biogenesis; cell division; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle; negative regulation of protein binding; phosphorylation; meiotic spindle organization and biogenesis; spindle assembly involved in female meiosis I; anterior/posterior axis specification; negative regulation of apoptosis
Research Articles on AURKA
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Product Notes
The Mouse AURKA aurka (Catalog #AAA9325153) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325153 ELISA Kit recognizes Mouse AURKA. It is sometimes possible for the material contained within the vial of "aurora kinase A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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