Human dual oxidase maturation factor 1 ELISA Kit | DUOXA1 elisa kit
Human Dual oxidase maturation factor 1, DUOXA1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Uniprot Description
DUOXA1: May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1 (Probable). Belongs to the DUOXA family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q21.1
Cellular Component: endoplasmic reticulum membrane; integral to membrane; plasma membrane
Biological Process: protein transport; regulation of inflammatory response; hydrogen peroxide metabolic process; positive regulation of neuron differentiation
Research Articles on DUOXA1
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Product Notes
The Human DUOXA1 duoxa1 (Catalog #AAA9324563) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324563 ELISA Kit recognizes Human DUOXA1. It is sometimes possible for the material contained within the vial of "dual oxidase maturation factor 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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