Human TAF4b RNA polymerase II, TATA box binding protein (TBP) -associated factor, 105kDa ELISA Kit | TAF4B elisa kit

Human Transcription initiation factor TFIID subunit 4B, TAF4B ELISA Kit

Cat. Num. AAA9317077

• Gene Names: TAF4B; SPGF13; TAF2C2; TAFII105
• Reactivity: Human
• Synonyms: TAF4b RNA polymerase II; TATA box binding protein (TBP) -associated factor; 105kDa; Human Transcription initiation factor TFIID subunit 4B; TAF4B ELISA Kit; Human Transcription initiation factor TFIID subunit 4B (TAF4B) ELISA kit; TAF2C2; TAFII105; TATA box binding protein (TBP) -associated factor 4B; RNA polymerase II; C2; 105kD; transcription initiation factor TFIID 105 kD subu; TAF4B elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 148792970
• NCBI GeneID: 6875
• NCBI Accession #: NP_005631.1
• NCBI GenBank Nucleotide #: NM_005640.2
• UniProt Accession #: Q92750; Q29YA4; Q29YA5
• Molecular Weight: 91,091 Da
• NCBI Official Full Name: transcription initiation factor TFIID subunit 4B isoform 2
• NCBI Official Synonym Full Names: TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
• NCBI Official Symbol: TAF4B
• NCBI Official Synonym Symbols: SPGF13; TAF2C2; TAFII105
• NCBI Protein Information: transcription initiation factor TFIID subunit 4B; TAF(II)105; TATA box binding protein (TBP)-associated factor 4B; transcription initiation factor TFIID 105 kDa subunit; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD
• UniProt Protein Name: Transcription initiation factor TFIID subunit 4B
• Protein Family: Transcription initiation factor
• UniProt Gene Name: TAF4B
• UniProt Synonym Gene Names: TAF2C2; TAFII105; TAF(II)105; TAFII-105; TAFII105
• UniProt Entry Name: TAF4B_HUMAN

NCBI Description

TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Uniprot Description

TAF4B: Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Belongs to the TAF4 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: nucleoplasm; transcription factor TFIID complex; cytoplasm; nucleolus

Molecular Function: NF-kappaB binding; DNA binding; protein heterodimerization activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; oogenesis; transcription initiation from RNA polymerase II promoter; viral reproduction; regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase II promoter; spermatogenesis; gene expression

Disease: Spermatogenic Failure 13