Western Blot (WB)
(The anti-LYK5 Pab is used in Western blot to detect LYK5 in mouse brain tissue lysate)
Rabbit LYK5 Polyclonal Antibody | anti-STRADA antibody
LYK5 Antibody (N-term)
Western Blot (WB)
(The anti-LYK5 Pab is used in Western blot to detect LYK5 in mouse brain tissue lysate)
Western Blot (WB)
(The anti-LYK5 Pab is used in Western blot to detect LYK5 in mouse brain tissue lysate)
Scanlan, M.J., et al., Cancer Immun. 1, 4 (2001).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]
Uniprot Description
STRAD: a pseudokinase which, in complex with CAB39, binds to and activates LKB1. Relocates LKB1 from the nucleus to the cytoplasm. Plays an essential role in LKB1-mediated G1 cell cycle arrest. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; Protein kinase, STE; Kinase, protein; STE group; STE20 family; STLK subfamily
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol
Molecular Function: protein serine/threonine kinase activator activity; protein binding; kinase binding; protein kinase activator activity; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity
Biological Process: insulin receptor signaling pathway; activation of protein kinase activity; mitotic cell cycle; protein export from nucleus; cell cycle arrest; protein amino acid phosphorylation
Disease: Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy
Research Articles on STRADA
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Product Notes
The STRADA strada (Catalog #AAA9210569) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 12-41. The LYK5 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's LYK5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the STRADA strada for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LYK5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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