ENY2 blocking peptide

ENY2 Blocking Peptide (N-term)

• Gene Names: ENY2; DC6; Sus1; e(y)2
• Synonyms: ENY2; ENY2 Blocking Peptide (N-term); Transcription and mRNA export factor ENY2 ; Enhancer of yellow 2 transcription factor homolog ; ENY2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 17-31 of HUMAN ENY2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 101

• Cellular Location: Nucleus, nucleoplasm. Nucleus, nuclear pore complex
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ENY2 blocking peptide

Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.

NCBI and Uniprot Product Information

• NCBI GI #: 9910186
• NCBI GeneID: 56943
• NCBI Accession #: NP_064574.1
• NCBI GenBank Nucleotide #: NM_020189.5
• UniProt Accession #: Q9NPA8; B2RE52; G3V117
• Molecular Weight: 10,984 Da
• NCBI Official Full Name: transcription and mRNA export factor ENY2 isoform 1
• NCBI Official Synonym Full Names: ENY2, transcription and export complex 2 subunit
• NCBI Official Symbol: ENY2
• NCBI Official Synonym Symbols: DC6; Sus1; e(y)2
• NCBI Protein Information: transcription and mRNA export factor ENY2
• UniProt Protein Name: Transcription and mRNA export factor ENY2
• Protein Family: Transcription and mRNA export factor
• UniProt Gene Name: ENY2
• UniProt Entry Name: ENY2_HUMAN

Uniprot Description

ENY2: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. May also participate in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Belongs to the ENY2 family.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 8q23.1

Molecular Function: chromatin binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription coactivator activity

Biological Process: histone deubiquitination; poly(A)+ mRNA export from nucleus; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter