NAT8L blocking peptide

NAT8L Blocking Peptide (N-Term)

Gene Names

NAT8L; CML3; NACED; NAT8-LIKE

Synonyms

NAT8L; NAT8L Blocking Peptide (N-Term); N-acetylaspartate synthetase; NAA synthetase; 2.3.1.17; Camello-like protein 3; N-acetyltransferase 8-like protein; CML3; NAT8L blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 79-93 of HUMAN NAT8L

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

302

Cellular Location

Cytoplasm. Membrane; Single- pass membrane protein. Microsome membrane; Single-pass membrane protein Mitochondrion membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane; Single-pass membrane protein. Note: Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment

Tissue Location

Expressed in brain.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NAT8L blocking peptide

Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake.

NCBI and Uniprot Product Information

NCBI GI #

259016335

NCBI GeneID

339983

UniProt Accession #

Q8N9F0; Q3UGX3; D3ZVU9

Molecular Weight

32,837 Da

NCBI Official Full Name

N-acetylaspartate synthetase

NCBI Official Synonym Full Names

N-acetyltransferase 8 like

NCBI Official Symbol

NAT8L

NCBI Official Synonym Symbols

CML3; NACED; NAT8-LIKE

NCBI Protein Information

N-acetylaspartate synthetase

UniProt Protein Name

N-acetylaspartate synthetase

Protein Family

N-acetylaspartate synthetase

UniProt Gene Name

NAT8L

UniProt Synonym Gene Names

CML3; NAA synthetase

UniProt Entry Name

NAT8L_HUMAN

NCBI Description

This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010]

Uniprot Description

NAT8L: Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. Defects in NAT8L are the cause of N-acetylaspartate deficiency (NACED). A metabolic disorder resulting in truncal ataxia, marked developmental delay, seizures, and secondary microcephaly. Belongs to the camello family.

Protein type: EC 2.3.1.17; Acetyltransferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: cytoplasm; mitochondrial membrane; mitochondrion

Molecular Function: aspartate N-acetyltransferase activity

Disease: N-acetylaspartate Deficiency

Research Articles on NAT8L

1. This study demonistrated that the human NAT8L gene related to reward dependence, a personality trait, and grey matter volume in the caudate nucleus in healthy subjects, suggesting that NAT8L might also affect human personality

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Product Notes

The NAT8L nat8l (Catalog #AAA9230520) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NAT8L, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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NAT8L blocking peptide