FCGR1A blocking peptide

FCGR1A Blocking Peptide (Center)

Gene Names

FCGR1A; CD64; FCRI; CD64A; IGFR1

Synonyms

FCGR1A; FCGR1A Blocking Peptide (Center); High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI; Fc-gamma RIA; FcgammaRIa; CD64; FCG1; FCGR1; IGFR1; FCGR1A blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 168-180 of HUMAN FCGR1A

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

374

Cellular Location

Cell membrane; Single-pass type I membrane protein Note: Stabilized at the cell membrane through interaction with FCER1G

Tissue Location

Monocyte/macrophage specific.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FCGR1A blocking peptide

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

NCBI and Uniprot Product Information

NCBI GI #

50403717

NCBI GeneID

2209

UniProt Accession #

P12314; P12315; Q5QNW7; Q92495; Q92663

Molecular Weight

38,795 Da

NCBI Official Full Name

High affinity immunoglobulin gamma Fc receptor I

NCBI Official Synonym Full Names

Fc fragment of IgG receptor Ia

NCBI Official Symbol

FCGR1A

NCBI Official Synonym Symbols

CD64; FCRI; CD64A; IGFR1

NCBI Protein Information

high affinity immunoglobulin gamma Fc receptor I

UniProt Protein Name

High affinity immunoglobulin gamma Fc receptor I

UniProt Gene Name

FCGR1A

UniProt Synonym Gene Names

FCG1; FCGR1; IGFR1; IgG Fc receptor I; FcRI; FcgammaRIa

UniProt Entry Name

FCGR1_HUMAN

NCBI Description

This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Description

FCGR1A: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Belongs to the immunoglobulin superfamily. FCGR1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21.2-q21.3

Cellular Component: early endosome membrane; plasma membrane

Molecular Function: protein binding; receptor signaling protein activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; immune response; phagocytosis, engulfment; receptor-mediated endocytosis; regulation of immune response; signal transduction

Research Articles on FCGR1A

1. Early RA patients display increased membrane and soluble CD64 and an impaired FcgammaR function correlating with joint disease activity.

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Product Notes

The FCGR1A fcgr1a (Catalog #AAA9230053) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FCGR1A, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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FCGR1A blocking peptide