PTPRZ1 blocking peptide

PTPRZ1 Blocking Peptide (N-term)

Gene Names

PTPRZ1; PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; PTP-ZETA; RPTPbeta; phosphacan; R-PTP-zeta-2

Synonyms

PTPRZ1; PTPRZ1 Blocking Peptide (N-term); Receptor-type tyrosine-protein phosphatase zeta; R-PTP-zeta; Protein-tyrosine phosphatase receptor type Z polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 2; R-PTP-zeta-2; HTPZP2; PTPRZ; PTPRZ2; PTPZ; PTPRZ1 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 446-460 of HUMAN PTPRZ1

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

2315

Cellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein. Secreted. Note: A secreted form is apparently generated by shedding of the extracellular domain

Tissue Location

Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PTPRZ1 blocking peptide

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).

NCBI and Uniprot Product Information

NCBI GI #

229485537

NCBI GeneID

5803

UniProt Accession #

P23471; O76043; Q9UDR6; A4D0W5; C9JFM0

Molecular Weight

162,663 Da

NCBI Official Full Name

Receptor-type tyrosine-protein phosphatase zeta

NCBI Official Synonym Full Names

protein tyrosine phosphatase, receptor type Z1

NCBI Official Symbol

PTPRZ1

NCBI Official Synonym Symbols

PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; PTP-ZETA; RPTPbeta; phosphacan; R-PTP-zeta-2

NCBI Protein Information

receptor-type tyrosine-protein phosphatase zeta

UniProt Protein Name

Receptor-type tyrosine-protein phosphatase zeta

Protein Family

Receptor-type tyrosine-protein phosphatase

UniProt Gene Name

PTPRZ1

UniProt Synonym Gene Names

HTPZP2; PTPRZ; PTPRZ2; PTPZ; R-PTP-zeta

UniProt Entry Name

PTPRZ_HUMAN

NCBI Description

This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

Uniprot Description

PTPRZ1: May be involved in the regulation of specific developmental processes in the CNS. Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor protein phosphatase, tyrosine; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 7q31.3

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity

Biological Process: central nervous system development; learning and/or memory; oligodendrocyte differentiation; protein amino acid dephosphorylation

Disease: Helicobacter Pylori Infection, Susceptibility To

Research Articles on PTPRZ1

1. Confirm contribution of PTPRZ1, and especially PTPRQ, in CRC carcinogenesis and demonstrated that PTPRQ expression is correlated with KRAS mutation.

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Product Notes

The PTPRZ1 ptprz1 (Catalog #AAA9229729) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PTPRZ1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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PTPRZ1 blocking peptide