SSPN blocking peptide

SSPN Blocking Peptide (N-term)

• Gene Names: SSPN; KRAG; NSPN; SPN1; SPN2; DAGA5
• Synonyms: SSPN; SSPN Blocking Peptide (N-term); Sarcospan; K-ras oncogene-associated protein; Kirsten-ras-associated protein; KRAG; SSPN blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 21-34 of Human SSPN
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 243

• Cellular Location: Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein Note: Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions.
• Tissue Location: Isoform 1 is expressed exclusively in heart and skeletal muscle. Isoform 2 is expressed in heart, skeletal muscle, thymus, prostate, testis, ovary, small intestine, colon and spleen
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SSPN blocking peptide

Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC.

NCBI and Uniprot Product Information

• NCBI GI #: 13431900
• NCBI GeneID: 8082
• UniProt Accession #: Q14714; B3KS67
• Molecular Weight: 15,820 Da
• NCBI Official Full Name: Sarcospan
• NCBI Official Synonym Full Names: sarcospan
• NCBI Official Symbol: SSPN
• NCBI Official Synonym Symbols: KRAG; NSPN; SPN1; SPN2; DAGA5
• NCBI Protein Information: sarcospan
• UniProt Protein Name: Sarcospan
• Protein Family: Sarcospan
• UniProt Gene Name: SSPN
• UniProt Synonym Gene Names: KRAG
• UniProt Entry Name: SSPN_HUMAN

NCBI Description

This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]

Uniprot Description

SSPN: Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12p11.2

Cellular Component: transport vesicle

Biological Process: cell adhesion; muscle contraction