TAS2R43 blocking peptide

TAS2R43 Blocking Peptide (Center)

Gene Names

TAS2R43; T2R43; T2R52

Synonyms

TAS2R43; TAS2R43 Blocking Peptide (Center); Taste receptor type 2 member 43; T2R43; Taste receptor type 2 member 52; T2R52; TAS2R43 blocking peptide

Ordering

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

309

Cellular Location

Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note: In airway epithelial cells, localizes to motile cilia

Tissue Location

Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells Expressed in airway epithelia.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TAS2R43 blocking peptide

Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity).

NCBI and Uniprot Product Information

NCBI GI #

374095447

NCBI GeneID

259289

UniProt Accession #

P59537; P59546; Q645X4

Molecular Weight

35,599 Da

NCBI Official Full Name

Taste receptor type 2 member 43

NCBI Official Synonym Full Names

taste 2 receptor member 43

NCBI Official Symbol

TAS2R43

NCBI Official Synonym Symbols

T2R43; T2R52

NCBI Protein Information

taste receptor type 2 member 43

UniProt Protein Name

Taste receptor type 2 member 43

Protein Family

Taste receptor

UniProt Gene Name

TAS2R43

UniProt Synonym Gene Names

T2R43; T2R52

UniProt Entry Name

T2R43_HUMAN

NCBI Description

TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]

Uniprot Description

TAS2R43: Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways. Belongs to the G-protein coupled receptor T2R family.

Protein type: Membrane protein, integral; GPCR, T2R family; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: integral to membrane; plasma membrane

Molecular Function: bitter taste receptor activity; taste receptor activity

Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste; G-protein coupled receptor protein signaling pathway

Research Articles on TAS2R43

1. those with at least one sensitive TAS2R38 allele (AP or PP genotype) were more likely to report rejecting liquid medications than were those without a taster allele (AA genotype

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Product Notes

The TAS2R43 tas2r43 (Catalog #AAA9228972) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TAS2R43, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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TAS2R43 blocking peptide