POLDIP3 blocking peptide

POLDIP3 Blocking Peptide (N-term)

• Gene Names: POLDIP3; SKAR; PDIP46
• Synonyms: POLDIP3; POLDIP3 Blocking Peptide (N-term); Polymerase delta-interacting protein 3; 46 kDa DNA polymerase delta interaction protein; p46; S6K1 Aly/REF-like target; SKAR; KIAA1649; PDIP46; POLDIP3 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 108-120 of HUMAN POLDIP3
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 421

• Cellular Location: Nucleus. Nucleus speckle. Cytoplasm. Note: Nucleocytoplasmic shuttling protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for POLDIP3 blocking peptide

Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.

NCBI and Uniprot Product Information

• NCBI GI #: 29837655
• NCBI GeneID: 84271
• NCBI Accession #: NP_115687.2
• NCBI GenBank Nucleotide #: NM_032311.4
• UniProt Accession #: Q9BY77; Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9NSP5; Q9NSP6; A8K6F8; A8K6V9
• Molecular Weight: 42,895 Da
• NCBI Official Full Name: polymerase delta-interacting protein 3 isoform 1
• NCBI Official Synonym Full Names: DNA polymerase delta interacting protein 3
• NCBI Official Symbol: POLDIP3
• NCBI Official Synonym Symbols: SKAR; PDIP46
• NCBI Protein Information: polymerase delta-interacting protein 3
• UniProt Protein Name: Polymerase delta-interacting protein 3
• Protein Family: Polymerase delta-interacting protein
• UniProt Gene Name: POLDIP3
• UniProt Synonym Gene Names: KIAA1649; PDIP46; p46; SKAR
• UniProt Entry Name: PDIP3_HUMAN

NCBI Description

This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

SKAR: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; nuclear speck; nucleoplasm

Molecular Function: protein binding

Biological Process: mRNA 3'-end processing; mRNA export from nucleus; poly(A)+ mRNA export from nucleus; positive regulation of translation; RNA export from nucleus; termination of RNA polymerase II transcription