Immunohistochemistry (IHC)
(Immunochemical staining LRRTM2 in human brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Rabbit anti-Human, Mouse LRRTM2 Polyclonal Antibody | anti-LRRTM2 antibody
Anti-LRRTM2 Antibody, Rabbit Polyclonal
Reactivity
Human, Mouse
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
LRRTM2; Polyclonal Antibody; Anti-LRRTM2 Antibody; Rabbit Polyclonal; LRRTM2 Antibody; Rabbit PAb; Antigen Affinity Purified; leucine rich repeat transmembrane neuronal 2; anti-LRRTM2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human LRRTM2
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-LRRTM2 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:500-1:2000
Immunogen
A synthetic peptide corresponding to the C-terminus of the Human LRRTM2
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human LRRTM2, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining LRRTM2 in human brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining LRRTM2 in human brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining LRRTM2 in mouse brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining LRRTM2 in mouse brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)
Related Product Information for anti-LRRTM2 antibody
LRRTM2 (Leucine-Rich Repeat Transmembrane Neuronal 2) is a Protein Coding gene. LRRTM2 belongs to the LRRTM family and is a key regulator of excitatory synapse development and function. It localizes to excitatory synapses in transfected hippocampal neurons, and shRNA-mediated knockdown of LRRTM2 leads to a decrease in excitatory synapses without affecting inhibitory synapses. LRRTM2 interacts with PSD-95 and regulates surface expression of AMPA receptors, and lentivirus-mediated knockdown of LRRTM2 in vivo decreases the strength of evoked excitatory synaptic currents. LRRTM2 induces only excitatory synapses, and that it also acts to induce synapses in transfected neurons similarly to neuroligin-1. Diseases associated with LRRTM2 include Tarp Syndrome and Histrionic Personality Disorder.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
59,076 Da
NCBI Official Full Name
leucine-rich repeat transmembrane neuronal protein 2
NCBI Official Synonym Full Names
leucine rich repeat transmembrane neuronal 2
NCBI Official Symbol
LRRTM2
NCBI Protein Information
leucine-rich repeat transmembrane neuronal protein 2; leucine-rich repeat neuronal 2 protein; leucine-rich repeat transmembrane neuronal 2 protein
UniProt Protein Name
Leucine-rich repeat transmembrane neuronal protein 2
Protein Family
UniProt Gene Name
LRRTM2
UniProt Synonym Gene Names
KIAA0416; LRRN2
UniProt Entry Name
LRRT2_HUMAN
Uniprot Description
LRRTM2: Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B. Belongs to the LRRTM family.
Protein type: Cell development/differentiation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: postsynaptic membrane; integral to membrane; excitatory synapse; cell junction
Molecular Function: neurexin binding
Biological Process: synapse organization and biogenesis; negative regulation of receptor internalization
Research Articles on LRRTM2
Similar Products
Product Notes
The LRRTM2 lrrtm2 (Catalog #AAA8100758) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-LRRTM2 Antibody, Rabbit Polyclonal reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's LRRTM2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:500-1:2000. Researchers should empirically determine the suitability of the LRRTM2 lrrtm2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LRRTM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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