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Western Blot (WB) (Western blot analysis of extracts from RAW264.7 cells, using POLDIP3 antibody.)

Rabbit anti-Human, Mouse POLDIP3 Polyclonal Antibody | anti-POLDIP3 antibody

POLDIP3 Antibody

Gene Names
POLDIP3; SKAR; PDIP46
Reactivity
Human, Mouse
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
POLDIP3; Polyclonal Antibody; POLDIP3 Antibody; 46 kDa DNA polymerase delta interaction protein; KIAA1649; p46; PDIP3; PDIP46; anti-POLDIP3 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total POLDIP3 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
421
Applicable Applications for anti-POLDIP3 antibody
Western Blot (WB)
Application Notes
Western blotting: 1:500~1:3000
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from internal of human POLDIP3.
Target Name
POLDIP3
Preparation and Storage
Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from RAW264.7 cells, using POLDIP3 antibody.)

Western Blot (WB) (Western blot analysis of extracts from RAW264.7 cells, using POLDIP3 antibody.)
Related Product Information for anti-POLDIP3 antibody
Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.Liu L., J. Biol. Chem. 278:10041-10047(2003).Hirosawa M., DNA Res. 8:1-9(2001).Collins J.E., Genome Res. 13:27-36(2003).
Product Categories/Family for anti-POLDIP3 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
42,895 Da
NCBI Official Full Name
polymerase delta-interacting protein 3 isoform 1
NCBI Official Synonym Full Names
polymerase (DNA-directed), delta interacting protein 3
NCBI Official Symbol
POLDIP3
NCBI Official Synonym Symbols
SKAR; PDIP46
NCBI Protein Information
polymerase delta-interacting protein 3
UniProt Protein Name
Polymerase delta-interacting protein 3
UniProt Gene Name
POLDIP3
UniProt Synonym Gene Names
KIAA1649; PDIP46; p46; SKAR
UniProt Entry Name
PDIP3_HUMAN

NCBI Description

This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

SKAR: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; nuclear speck

Molecular Function: protein binding; nucleotide binding

Biological Process: poly(A)+ mRNA export from nucleus; positive regulation of translation

Research Articles on POLDIP3

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Product Notes

The POLDIP3 poldip3 (Catalog #AAA9406016) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The POLDIP3 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's POLDIP3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500~1:3000. Researchers should empirically determine the suitability of the POLDIP3 poldip3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "POLDIP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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