CLCN5 blocking peptide

CLCN5 Blocking Peptide (N-term)

Gene Names

CLCN5; XRN; CLC5; XLRH; CLCK2; ClC-5; DENTS; NPHL1; NPHL2; hCIC-K2

Synonyms

CLCN5; CLCN5 Blocking Peptide (N-term); H(+)/Cl(-) exchange transporter 5; Chloride channel protein 5; ClC-5; Chloride transporter ClC-5; CLCK2; CLCN5 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 30-41 of HUMAN CLCN5

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

746

Cellular Location

Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein

Tissue Location

Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CLCN5 blocking peptide

Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.

NCBI and Uniprot Product Information

NCBI GI #

4557473

NCBI GeneID

1184

NCBI Accession #

NP_000075.1

NCBI GenBank Nucleotide #

NM_000084.4

UniProt Accession #

P51795; Q5JQD5; Q7RTN8; A1L475; B3KPN6

Molecular Weight

90,785 Da

NCBI Official Full Name

H(+)/Cl(-) exchange transporter 5 isoform b

NCBI Official Synonym Full Names

chloride voltage-gated channel 5

NCBI Official Symbol

CLCN5

NCBI Official Synonym Symbols

XRN; CLC5; XLRH; CLCK2; ClC-5; DENTS; NPHL1; NPHL2; hCIC-K2

NCBI Protein Information

H(+)/Cl(-) exchange transporter 5

UniProt Protein Name

H(+)/Cl(-) exchange transporter 5

Protein Family

H(+)/Cl(-) exchange transporter

UniProt Gene Name

CLCN5

UniProt Synonym Gene Names

CLCK2; ClC-5

UniProt Entry Name

CLCN5_HUMAN

NCBI Description

This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

Uniprot Description

Research Articles on CLCN5

1. Previously reported mutations and their associated phenotype in 377 male patients with Dent disease are reviewed and described phenotype and novel and recurrent mutations in a large cohort of 117 Dent disease patients belonging to 90 families.

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Product Notes

The CLCN5 clcn5 (Catalog #AAA9228765) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CLCN5, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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CLCN5 blocking peptide