VWA2 blocking peptide

VWA2 Blocking Peptide (N-term)

• Gene Names: VWA2; AMACO; NET42; CCSP-2
• Synonyms: VWA2; VWA2 Blocking Peptide (N-term); von Willebrand factor A domain-containing protein 2; A domain-containing protein similar to matrilin and collagen; AMACO; Colon cancer secreted protein 2; CCSP-2; VWA2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 59-72 of HUMAN VWA2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 421

• Cellular Location: Secreted.
• Tissue Location: Expression is generally absent in normal colon and other normal body tissues, but it is induced an average of 78- fold in Stage II, III, and IV colon cancers, as well as in colon adenomas and colon cancer cell lines
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 38348304
• NCBI GeneID: 340706
• NCBI Accession #: NP_940898.1
• NCBI GenBank Nucleotide #: NM_198496.1
• UniProt Accession #: Q5GFL6; Q6ZS39; Q6ZWJ7; Q708C5; Q70UZ8; A1A5D4; B5MDJ8
• Molecular Weight: 45,345 Da
• NCBI Official Synonym Full Names: von Willebrand factor A domain containing 2
• NCBI Official Symbol: VWA2
• NCBI Official Synonym Symbols: AMACO; NET42; CCSP-2
• NCBI Protein Information: von Willebrand factor A domain-containing protein 2
• UniProt Protein Name: von Willebrand factor A domain-containing protein 2
• Protein Family: von Willebrand factor A domain-containing protein
• UniProt Gene Name: VWA2
• UniProt Synonym Gene Names: AMACO; AMACO; CCSP-2
• UniProt Entry Name: VWA2_HUMAN

NCBI Description

This gene encodes a member of the von Willebrand factor A-like domain protein superfamily. The encoded protein is localized to the extracellular matrix and may serve as a structural component in basement membranes or in anchoring structures on scaffolds of collagen VII or fibrillin. This gene has been linked to type 1A diabetes and is a candidate serological marker for colon cancer. [provided by RefSeq, Jan 2013]

Uniprot Description

VWA2: 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 10q25.3

Cellular Component: extracellular space

Molecular Function: identical protein binding; protein binding

Biological Process: protein homooligomerization; regulation of insulin receptor signaling pathway