TMPRSS3 blocking peptide

TMPRSS3 Antibody (Center) Blocking Peptide

• Gene Names: TMPRSS3; DFNB8; DFNB10; ECHOS1; TADG12
• Synonyms: TMPRSS3; TMPRSS3 Antibody (Center) Blocking Peptide; Transmembrane protease serine 3; 3421-; Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein; ECHOS1; TADG12; TMPRSS3 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human TMPRSS3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 454

• Cellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
• Tissue Location: Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TMPRSS3 blocking peptide

Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).

NCBI and Uniprot Product Information

• NCBI GI #: 13124582
• NCBI GeneID: 64699
• UniProt Accession #: P57727; Q5USC7; Q6ZMC3; D3DSJ6
• Molecular Weight: 58,324 Da
• NCBI Official Full Name: Transmembrane protease serine 3
• NCBI Official Synonym Full Names: transmembrane protease, serine 3
• NCBI Official Symbol: TMPRSS3
• NCBI Official Synonym Symbols: DFNB8; DFNB10; ECHOS1; TADG12
• NCBI Protein Information: transmembrane protease serine 3
• UniProt Protein Name: Transmembrane protease serine 3
• Protein Family: Transmembrane protease serine
• UniProt Gene Name: TMPRSS3
• UniProt Synonym Gene Names: ECHOS1; TADG12
• UniProt Entry Name: TMPS3_HUMAN

NCBI Description

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

Uniprot Description

TMPRSS3: Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8). DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10). Belongs to the peptidase S1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Membrane protein, integral; Endoplasmic reticulum; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane

Molecular Function: sodium channel regulator activity

Biological Process: cellular sodium ion homeostasis

Disease: Deafness, Autosomal Recessive 8