C Blocking Peptide | CRAT blocking peptide

CRAT Antibody (N-term) Blocking Peptide

• Gene Names: CRAT; CAT1
• Synonyms: C; CRAT Antibody (N-term) Blocking Peptide; Carnitine O-acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; CrAT; CRAT; CAT1; CRAT blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human CRAT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 626

• Cellular Location: Endoplasmic reticulum. Peroxisome. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side Isoform 2: Peroxisome.
• Tissue Location: Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CRAT blocking peptide

Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.

NCBI and Uniprot Product Information

• NCBI GI #: 215274265
• NCBI GeneID: 1384
• UniProt Accession #: P43155; Q5T952; Q9BW16
• Molecular Weight: 61,870 Da
• NCBI Official Full Name: Carnitine O-acetyltransferase
• NCBI Official Synonym Full Names: carnitine O-acetyltransferase
• NCBI Official Symbol: CRAT
• NCBI Official Synonym Symbols: CAT1
• NCBI Protein Information: carnitine O-acetyltransferase
• UniProt Protein Name: Carnitine O-acetyltransferase
• Protein Family: CD2
• UniProt Gene Name: CRAT
• UniProt Synonym Gene Names: CAT1; Carnitine acetylase; CAT; CrAT
• UniProt Entry Name: CACP_HUMAN

NCBI Description

This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Description

CRAT: Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria. Belongs to the carnitine/choline acetyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.3.1.7; Mitochondrial; Acetyltransferase

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: mitochondrion; peroxisomal matrix; peroxisome

Molecular Function: carnitine O-acetyltransferase activity; receptor binding

Biological Process: carnitine metabolic process, CoA-linked; fatty acid beta-oxidation using acyl-CoA oxidase