Myosin 1C (MYO1C) Blocking Peptide | MYO1C blocking peptide

Myosin 1C (MYO1C) Antibody (C-term) Blocking peptide

• Gene Names: MYO1C; NMI; MMIb; myr2; MMI-beta
• Synonyms: Myosin 1C (MYO1C); Myosin 1C (MYO1C) Antibody (C-term) Blocking peptide; Unconventional myosin-Ic; Myosin I beta; MMI-beta; MMIb; MYO1C; MYO1C blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human MYO1C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1063

• Cellular Location: Isoform 1: Cytoplasm. Nucleus. Note: Colocalizes with RNA polymerase II. Absent from nucleoli and does not colocalize with RNA polymerase I. Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription Isoform 3: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex. Note: Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MYO1C blocking peptide

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.

NCBI and Uniprot Product Information

• NCBI GI #: 317373577
• NCBI GeneID: 4641
• UniProt Accession #: O00159; Q4LE56; Q6NVJ7; Q86Y95
• Molecular Weight: 119,628 Da
• NCBI Official Full Name: Unconventional myosin-Ic
• NCBI Official Synonym Full Names: myosin IC
• NCBI Official Symbol: MYO1C
• NCBI Official Synonym Symbols: NMI; MMIb; myr2; MMI-beta
• NCBI Protein Information: unconventional myosin-Ic
• UniProt Protein Name: Unconventional myosin-Ic
• Protein Family: Unconventional myosin
• UniProt Gene Name: MYO1C
• UniProt Synonym Gene Names: MMI-beta; MMIb
• UniProt Entry Name: MYO1C_HUMAN

NCBI Description

This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]

Uniprot Description

MYO1C: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor; Lipid-binding; Nucleolus; Actin-binding; Contractile

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: basal plasma membrane; cytoplasm; cytosol; filamentous actin; lateral plasma membrane; lipid raft; membrane; microvillus; nucleoplasm; plasma membrane; stress fiber; unconventional myosin complex

Molecular Function: protein binding; Ral GTPase binding; receptor binding

Biological Process: positive regulation of cell migration; positive regulation of gene expression, epigenetic; protein targeting; protein targeting to membrane