Western Blot (WB)
(Western blot analysis of MYO1C Antibody (C-term) in K562 cell line lysates (35ug/lane). MYO1C (arrow) was detected using the purified Pab.)
Rabbit Myosin 1C (MYO1C) Polyclonal Antibody | anti-MYO1C antibody
Myosin 1C (MYO1C) Antibody (C-term)
Western Blot (WB)
(Western blot analysis of MYO1C Antibody (C-term) in K562 cell line lysates (35ug/lane). MYO1C (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of MYO1C Antibody (C-term) in K562 cell line lysates (35ug/lane). MYO1C (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with MYO1C antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with MYO1C antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]
Uniprot Description
MYO1C: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; Motor; Lipid-binding; Actin-binding; Motility/polarity/chemotaxis; Contractile
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: myosin I complex; microvillus; mitochondrion; cytoplasmic membrane-bound vesicle; nuclear pore; cytosol; lipid raft; nucleoplasm; filamentous actin; ruffle; membrane; cytoplasm; basal plasma membrane; unconventional myosin complex; nucleolus; stress fiber; plasma membrane; brush border; lateral plasma membrane
Molecular Function: calmodulin binding; protein C-terminus binding; protein binding; motor activity; Ral GTPase binding; actin-dependent ATPase activity; actin binding; ATP binding; receptor binding
Biological Process: mRNA transport; metabolic process; innate immune response; protein targeting to membrane; protein targeting; positive regulation of cell migration
Research Articles on MYO1C
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Product Notes
The MYO1C myo1c (Catalog #AAA9203741) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 911-940. The Myosin 1C (MYO1C) Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's Myosin 1C (MYO1C) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the MYO1C myo1c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Myosin 1C (MYO1C), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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