SLC22A4 blocking peptide

SLC22A4 Antibody (C-term) Blocking peptide

• Gene Names: SLC22A4; OCTN1
• Synonyms: SLC22A4; SLC22A4 Antibody (C-term) Blocking peptide; Solute carrier family 22 member 4; Ergothioneine transporter; ET transporter; Organic cation/carnitine transporter 1; ETT; OCTN1; UT2H; SLC22A4 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 551

• Cellular Location: Membrane; Multi-pass membrane protein.
• Tissue Location: Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SLC22A4 blocking peptide

Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).

NCBI and Uniprot Product Information

• NCBI GI #: 24497490
• NCBI GeneID: 6583
• NCBI Accession #: NP_003050.2
• NCBI GenBank Nucleotide #: NM_003059.2
• UniProt Accession #: Q9H015; O14546
• Molecular Weight: 62,155 Da
• NCBI Official Full Name: solute carrier family 22 member 4
• NCBI Official Synonym Full Names: solute carrier family 22 member 4
• NCBI Official Symbol: SLC22A4
• NCBI Official Synonym Symbols: OCTN1
• NCBI Protein Information: solute carrier family 22 member 4
• UniProt Protein Name: Solute carrier family 22 member 4
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC22A4
• UniProt Synonym Gene Names: ETT; OCTN1; UT2H; ET transporter
• UniProt Entry Name: S22A4_HUMAN

NCBI Description

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]

Uniprot Description

SLC22A4: Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). Genetic variations in SLC22A4 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family; Mitochondrial

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: apical plasma membrane; integral to plasma membrane; mitochondrion; plasma membrane

Molecular Function: carnitine transporter activity; cation:cation antiporter activity; nucleotide binding; PDZ domain binding; protein binding; quaternary ammonium group transmembrane transporter activity; secondary active organic cation transmembrane transporter activity

Biological Process: body fluid secretion; carnitine metabolic process; carnitine transport; organic cation transport; quaternary ammonium group transport

Disease: Rheumatoid Arthritis