CMPK2 blocking peptide

CMPK2 Antibody (Center) Blocking peptide

• Gene Names: CMPK2; NDK; TYKi; TMPK2; UMP-CMPK2
• Synonyms: CMPK2; CMPK2 Antibody (Center) Blocking peptide; UMP-CMP kinase 2; mitochondrial; Nucleoside-diphosphate kinase; CMPK2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 449

• Cellular Location: Mitochondrion.
• Tissue Location: Among all investigated tumors, leukemia cells show the most abundant expression.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CMPK2 blocking peptide

May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.

NCBI and Uniprot Product Information

• NCBI GI #: 296439392
• NCBI GeneID: 129607
• UniProt Accession #: Q5EBM0; Q6ZRU2; Q96AL8; A2RUB0; A5D8T2; B7ZM18
• Molecular Weight: 44,959 Da
• NCBI Official Full Name: UMP-CMP kinase 2, mitochondrial
• NCBI Official Synonym Full Names: cytidine/uridine monophosphate kinase 2
• NCBI Official Symbol: CMPK2
• NCBI Official Synonym Symbols: NDK; TYKi; TMPK2; UMP-CMPK2
• NCBI Protein Information: UMP-CMP kinase 2, mitochondrial
• UniProt Protein Name: UMP-CMP kinase 2, mitochondrial
• UniProt Gene Name: CMPK2
• UniProt Entry Name: CMPK2_HUMAN

NCBI Description

This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Description

CMPK2: May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Belongs to the thymidylate kinase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - pyrimidine; Kinase, other; EC 2.7.4.6; EC 2.7.4.14

Chromosomal Location of Human Ortholog: 2p25.2

Cellular Component: cytosol; mitochondrion; nucleoplasm; nucleus

Molecular Function: cytidylate kinase activity; nucleoside diphosphate kinase activity; thymidylate kinase activity; UMP kinase activity

Biological Process: dTDP biosynthetic process; dTTP biosynthetic process; dUDP biosynthetic process; nucleoside diphosphate phosphorylation; nucleoside triphosphate biosynthetic process