AMOT (Y599) Blocking Peptide | AMOT blocking peptide
Phospho-AMOT(Y599) Antibody Blocking peptide
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
AMOT: Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Belongs to the angiomotin family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: Xq23
Cellular Component: actin filament; cytosol; endocytic vesicle; external side of plasma membrane; lamellipodium; ruffle; signalosome
Molecular Function: angiostatin binding; protein binding; receptor activity
Biological Process: actin cytoskeleton organization and biogenesis; negative regulation of angiogenesis; regulation of cell migration
Research Articles on AMOT
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Product Notes
The AMOT amot (Catalog #AAA9225320) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AMOT (Y599), Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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