TULP3 blocking peptide

TULP3 Antibody (C-term) Blocking Peptide

• Gene Names: TULP3; TUBL3
• Synonyms: TULP3; TULP3 Antibody (C-term) Blocking Peptide; Tubby-related protein 3; Tubby-like protein 3; TUBL3; TULP3 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 442

• Cellular Location: Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm. Secreted. Note: Does not have a cleavable signal peptide and is secreted by a non- conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide- binding protein G(q) subunit alpha.
• Tissue Location: Expressed at high levels in testis, ovaries, thyroid, and spinal chord.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TULP3 blocking peptide

Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 125987867
• NCBI GeneID: 7289
• UniProt Accession #: O75386; Q8N5B0; B3KNB7; B7Z6A2; D3DUQ4; F8WBZ9
• Molecular Weight: 19,273 Da
• NCBI Official Full Name: Tubby-related protein 3
• NCBI Official Synonym Full Names: tubby like protein 3
• NCBI Official Symbol: TULP3
• NCBI Official Synonym Symbols: TUBL3
• NCBI Protein Information: tubby-related protein 3
• UniProt Protein Name: Tubby-related protein 3
• Protein Family: Tubby-related protein
• UniProt Gene Name: TULP3
• UniProt Synonym Gene Names: TUBL3
• UniProt Entry Name: TULP3_HUMAN

NCBI Description

This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009]

Uniprot Description

TULP3: Negatively regulates SHH signal transduction. Probably functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to phosphorylated inositide lipids. Belongs to the TUB family.

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: cilium; nucleolus; nucleus; plasma membrane

Molecular Function: enzyme binding; phosphoinositide binding; protein binding; protein complex binding

Biological Process: negative regulation of smoothened signaling pathway; regulation of G-protein coupled receptor protein signaling pathway