Ryk blocking peptide

Mouse Ryk Antibody (Center) Blocking Peptide

• Gene Names: Ryk; Vik; ERK-3; AW536699
• Synonyms: Ryk; Mouse Ryk Antibody (Center) Blocking Peptide; Tyrosine-protein kinase RYK; Kinase VIK; Met-related kinase; NYK-R; Mrk; Ryk blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 594

• Cellular Location: Membrane; Single-pass type I membrane protein Nucleus. Cytoplasm. Note: In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus
• Tissue Location: Is detected in all the tissues. Highest levels are seen in the ovary, lung and placenta
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Ryk blocking peptide

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

NCBI and Uniprot Product Information

• NCBI GI #: 547811
• NCBI GeneID: 20187
• UniProt Accession #: Q01887; Q61890
• Molecular Weight: 66,285 Da
• NCBI Official Full Name: Tyrosine-protein kinase RYK
• NCBI Official Synonym Full Names: receptor-like tyrosine kinase
• NCBI Official Symbol: Ryk
• NCBI Official Synonym Symbols: Vik; ERK-3; AW536699
• NCBI Protein Information: tyrosine-protein kinase RYK
• UniProt Protein Name: Tyrosine-protein kinase RYK
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: Ryk
• UniProt Synonym Gene Names: Mrk
• UniProt Entry Name: RYK_MOUSE

Uniprot Description

RYK: a receptor tyrosine kinase of the Ryk family. Associates with, and may modulate the signaling of, EphB2 and EphB3. Expressed in nestin-positive progenitor cells and neurons, some oligodendrocytes, O-2A progenitor cells, and type-2 astrocytes in developing CNS.

Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; EC 2.7.10.1; TK group; Ryk family

Cellular Component: cytoplasm; membrane; nucleus; plasma membrane

Molecular Function: frizzled binding; protein binding; protein-tyrosine kinase activity; transmembrane receptor activity; Wnt receptor activity; Wnt-protein binding

Biological Process: axon guidance; axonogenesis; corpus callosum development; negative chemotaxis; negative regulation of axon extension involved in axon guidance; neurite development; neuron differentiation; positive regulation of MAPKKK cascade; skeletal morphogenesis; Wnt receptor signaling pathway