Rabbit anti-Human COL6A2 Polyclonal Antibody | anti-COL6A2 antibody

COL6A2, CT (COL6A2, Collagen alpha-2(VI) chain)

Cat. Num. AAA649022

• Gene Names: COL6A2; PP3610
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: COL6A2; Polyclonal Antibody; CT (COL6A2; Collagen alpha-2(VI) chain); Anti -COL6A2; anti-COL6A2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-COL6A2 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: COL6A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-748 amino acids from the C-terminal region of human COL6A2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(COL6A2 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the COL6A2 antibody detected the COL6A2 protein (arrow).)

Related Product Information for anti-COL6A2 antibody

COL6A2 is one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The product of this gene contains several domains similar to von Willebrand Factor type A domains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in this gene are associated with Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. Three transcript variants have been identified for this gene. [provided by RefSeq].

Product Categories/Family for anti-COL6A2 antibody

Antibodies; Abs to Collagen

NCBI and Uniprot Product Information

• NCBI GI #: 115527070
• NCBI GeneID: 1292
• NCBI Accession #: NP_478055.2
• NCBI GenBank Nucleotide #: NM_058175.2
• UniProt Accession #: P12110; Q13909; Q13910; Q13911; Q14048; Q14049; Q16259; Q16597; Q6P0Q1; Q9UML3; Q9Y4S8
• Molecular Weight: 108,579 Da
• NCBI Official Full Name: collagen alpha-2(VI) chain isoform 2C2a'
• NCBI Official Synonym Full Names: collagen, type VI, alpha 2
• NCBI Official Symbol: COL6A2
• NCBI Official Synonym Symbols: PP3610
• NCBI Protein Information: collagen alpha-2(VI) chain; collagen alpha-2(VI) chain; collagen VI, alpha-2 polypeptide; human mRNA for collagen VI alpha-2 C-terminal globular domain
• UniProt Protein Name: Collagen alpha-2(VI) chain
• Protein Family: Collagen
• UniProt Gene Name: COL6A2
• UniProt Entry Name: CO6A2_HUMAN

NCBI Description

This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The product of this gene contains several domains similar to von Willebrand Factor type A domains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in this gene are associated with Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. Three transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Collagen VI acts as a cell-binding protein.

Subunit structure: Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-5(VI) or alpha-6(VI). Interacts with CSPG4. Ref.14

Subcellular location: Secreted › extracellular space › extracellular matrix. Membrane; Peripheral membrane protein. Note: Recruited on membranes by CSPG4. Ref.13

Post-translational modification: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Involvement in disease: Bethlem myopathy (BM) [MIM:158810]: A benign autosomal dominant proximal myopathy characterized by early childhood onset and joint contractures most frequently affecting the elbows and ankles.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17 Ref.18 Ref.20 Ref.21Ullrich congenital muscular dystrophy (UCMD) [MIM:254090]: UCMD is a congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.19 Ref.20Myosclerosis autosomal recessive (MYOSAR) [MIM:255600]: A condition characterized by chronic inflammation of skeletal muscle with hyperplasia of the interstitial connective tissue. The clinical picture includes slender muscles with firm 'woody' consistency and restriction of movement of many joints because of muscle contractures.Note: The disease is caused by mutations affecting the gene represented in this entry.

Sequence similarities: Belongs to the type VI collagen family.Contains 3 VWFA domains.