USP17L2 blocking peptide

USP17L2 Antibody (C-term) Blocking Peptide

• Gene Names: USP17L2; DUB3; DUB-3; USP17
• Synonyms: USP17L2; USP17L2 Antibody (C-term) Blocking Peptide; Ubiquitin carboxyl-terminal hydrolase 17; USP17; Deubiquitinating enzyme 17-like protein 2; Deubiquitinating protein 3; DUB-3; Ubiquitin carboxyl-terminal hydrolase 17-like protein 2; Ubiquitin thioesterase 17-like protein 2; Ubiquitin-specific-processing protease 17-like protein 2; USP17L2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 530

• Cellular Location: Nucleus. Endoplasmic reticulum.
• Tissue Location: Broadly expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for USP17L2 blocking peptide

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.

NCBI and Uniprot Product Information

• NCBI GI #: 187663988
• NCBI GeneID: 377630
• UniProt Accession #: Q6R6M4
• Molecular Weight: 59,619 Da
• NCBI Official Full Name: Ubiquitin carboxyl-terminal hydrolase 17
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 17-like family member 2
• NCBI Official Symbol: USP17L2
• NCBI Official Synonym Symbols: DUB3; DUB-3; USP17
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 17
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 17
• UniProt Gene Name: USP17L2
• UniProt Synonym Gene Names: DUB3; USP17; USP17H; USP17I; USP17J; USP17K; USP17L; USP17M; USP17; DUB-3
• UniProt Entry Name: U17L2_HUMAN

NCBI Description

DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM, Mar 2008]

Uniprot Description

DUB3: Deubiquitinating enzyme that specifically removes conjugated ubiquitin from CDC25A, thereby playing a key role in cell cycle regulation. Deubiquitination of CDC25A prevents its degradation by the proteasome during the G1/S and G2/M phases of the cell cycle and is required for cell-cycle progression. Has transforming capabilities on cell lines. May also function in cell apoptosis. Belongs to the peptidase C19 family. USP17 subfamily.

Protein type: EC 3.4.19.12; Protease; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: endoplasmic reticulum membrane; nucleus

Molecular Function: protein binding; ubiquitin-specific protease activity

Biological Process: cell cycle checkpoint; mitotic cell cycle checkpoint; negative regulation of histone deacetylation; positive regulation of GTPase activity; protein deubiquitination; regulation of apoptosis; regulation of cell migration; regulation of cell proliferation; regulation of defense response to virus by host