THRAP3 blocking peptide
THRAP3 Antibody (C-term) Blocking Peptide
Gene Names
THRAP3; TRAP150
Synonyms
THRAP3; THRAP3 Antibody (C-term) Blocking Peptide; Thyroid hormone receptor-associated protein 3; Thyroid hormone receptor-associated protein complex 150 kDa component; Trap150; TRAP150; THRAP3 blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
955
Cellular Location
Nucleus
Tissue Location
Ubiquitous..
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for THRAP3 blocking peptide
Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
108,666 Da
NCBI Official Full Name
Thyroid hormone receptor-associated protein 3
NCBI Official Synonym Full Names
thyroid hormone receptor associated protein 3
NCBI Official Symbol
THRAP3
NCBI Official Synonym Symbols
TRAP150
NCBI Protein Information
thyroid hormone receptor-associated protein 3
UniProt Protein Name
Thyroid hormone receptor-associated protein 3
Protein Family
UniProt Gene Name
THRAP3
UniProt Synonym Gene Names
TRAP150; Trap150
UniProt Entry Name
TR150_HUMAN
Uniprot Description
Trap150: Plays a role in transcriptional coactivation.
Protein type: Transcription, coactivator/corepressor; RNA-binding
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component: nuclear speck; nucleoplasm; nucleus; Srb-mediator complex
Molecular Function: phosphoprotein binding; protein binding; receptor activity; thyroid hormone receptor binding; transcription coactivator activity; transcription cofactor activity
Biological Process: androgen receptor signaling pathway; mRNA stabilization; positive regulation of circadian rhythm; positive regulation of nuclear mRNA splicing, via spliceosome; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of alternative nuclear mRNA splicing, via spliceosome; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter
Research Articles on THRAP3
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Product Notes
The THRAP3 thrap3 (Catalog #AAA9221740) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "THRAP3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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