SNX2 blocking peptide

SNX2 Antibody (C-term) Blocking Peptide

• Gene Names: SNX2; TRG-9
• Synonyms: SNX2; SNX2 Antibody (C-term) Blocking Peptide; Sorting nexin-2; Transformation-related gene 9 protein; TRG-9; SNX2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 519

• Cellular Location: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium Note: Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (PubMed:20604901).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SNX2 blocking peptide

Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901).

NCBI and Uniprot Product Information

• NCBI GI #: 110826413
• NCBI GeneID: 6643
• UniProt Accession #: O60749; O43650; P82862; Q53XK8; Q597H6; Q9BTS8; B3KN44; B4DEK4; B7Z408
• Molecular Weight: 46,098 Da
• NCBI Official Full Name: Sorting nexin-2
• NCBI Official Synonym Full Names: sorting nexin 2
• NCBI Official Symbol: SNX2
• NCBI Official Synonym Symbols: TRG-9
• NCBI Protein Information: sorting nexin-2
• UniProt Protein Name: Sorting nexin-2
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX2
• UniProt Synonym Gene Names: TRG-9
• UniProt Entry Name: SNX2_HUMAN

NCBI Description

This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. [provided by RefSeq, May 2013]

Uniprot Description

SNX2: May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Belongs to the sorting nexin family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 5q23

Cellular Component: cytoplasm; endosome membrane; extrinsic to membrane; membrane; protein complex; retromer complex

Molecular Function: epidermal growth factor receptor binding; insulin receptor binding; phosphoinositide binding; protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: endocytosis; protein oligomerization; retrograde transport, endosome to Golgi; vesicle organization and biogenesis