KRAS2 Blocking Peptide | KRAS blocking peptide

KRAS2 Antibody (C-term) Blocking Peptide

• Gene Names: KRAS; NS; NS3; CFC2; RALD; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B
• Synonyms: KRAS2; KRAS2 Antibody (C-term) Blocking Peptide; GTPase KRas; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; N-terminally processed; KRAS; RASK2; KRAS blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 189

• Cellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for KRAS blocking peptide

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838).

NCBI and Uniprot Product Information

• NCBI GI #: 131875
• NCBI GeneID: 3845
• UniProt Accession #: P01116; P01118; Q96D10; A8K8Z5; B0LPF9
• Molecular Weight: 21,425 Da
• NCBI Official Full Name: GTPase KRas
• NCBI Official Synonym Full Names: KRAS proto-oncogene, GTPase
• NCBI Official Symbol: KRAS
• NCBI Official Synonym Symbols: NS; NS3; CFC2; RALD; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B
• NCBI Protein Information: GTPase KRas
• UniProt Protein Name: GTPase KRas
• Protein Family: GTPase
• UniProt Gene Name: KRAS
• UniProt Synonym Gene Names: KRAS2; RASK2
• UniProt Entry Name: RASK_HUMAN

NCBI Description

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

Uniprot Description

KRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric; G protein, monomeric, Ras; Oncoprotein; Motility/polarity/chemotaxis; G protein

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; focal adhesion; membrane; plasma membrane

Molecular Function: protein binding; protein complex binding

Biological Process: axon guidance; epidermal growth factor receptor signaling pathway; leukocyte migration; MAPKKK cascade; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; Ras protein signal transduction; regulation of protein stability; stimulatory C-type lectin receptor signaling pathway

Disease: Bladder Cancer; Breast Cancer; Cardiofaciocutaneous Syndrome 2; Gastric Cancer, Hereditary Diffuse; Leukemia, Acute Myeloid; Lung Cancer; Noonan Syndrome 3; Pancreatic Cancer; Schimmelpenning-feuerstein-mims Syndrome