Fgfr1 blocking peptide

Mouse Fgfr1 Antibody (C-term) Blocking Peptide

• Gene Names: Fgfr1; FLG; MFR; Eask; Hspy; Flt-2; c-fgr; Fgfr-1; AW208770; bFGF-R-1
• Synonyms: Fgfr1; Mouse Fgfr1 Antibody (C-term) Blocking Peptide; Fibroblast growth factor receptor 1; FGFR-1; bFGF-R-1; Basic fibroblast growth factor receptor 1; MFR; Proto-oncogene c-Fgr; CD331; Flg; Fgfr1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 822

• Cellular Location: Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle Note: After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus Isoform 5: Cell membrane; Single-pass type I membrane protein
• Tissue Location: Widely expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Fgfr1 blocking peptide

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 120047
• NCBI GeneID: 14182
• UniProt Accession #: P16092; Q01736; Q60830; Q61562; Q80T10; Q8CFK8; Q9QZM7; E9Q2P4
• Molecular Weight: 91,669 Da
• NCBI Official Full Name: Fibroblast growth factor receptor 1
• NCBI Official Synonym Full Names: fibroblast growth factor receptor 1
• NCBI Official Symbol: Fgfr1
• NCBI Official Synonym Symbols: FLG; MFR; Eask; Hspy; Flt-2; c-fgr; Fgfr-1; AW208770; bFGF-R-1
• NCBI Protein Information: fibroblast growth factor receptor 1
• UniProt Protein Name: Fibroblast growth factor receptor 1
• Protein Family: FGFR1 oncogene partner
• UniProt Gene Name: Fgfr1
• UniProt Synonym Gene Names: Flg; FGFR-1; bFGF-R-1
• UniProt Entry Name: FGFR1_MOUSE

Uniprot Description

FGFR1: a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 20 isoforms of the human protein produced by alternative splicing have been described.

Protein type: Kinase, protein; Protein kinase, TK; Membrane protein, integral; Oncoprotein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; FGFR family

Cellular Component: cytoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; receptor complex

Molecular Function: cell adhesion molecule binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; glycoprotein binding; heparin binding; identical protein binding; protein binding; protein complex binding; protein homodimerization activity; protein-tyrosine kinase activity

Biological Process: angiogenesis; auditory receptor cell development; blood vessel morphogenesis; brain development; cell maturation; central nervous system neuron development; chondrocyte differentiation; embryonic limb morphogenesis; fibroblast growth factor receptor signaling pathway; generation of neurons; in utero embryonic development; induction of an organ; inner ear morphogenesis; lung development; mesenchymal cell differentiation; midbrain development; middle ear morphogenesis; motogenic signaling involved in postnatal olfactory bulb interneuron migration; negative regulation of osteoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; neurite development; neuroblast division in the ventricular zone; orbitofrontal cortex development; outer ear morphogenesis; paraxial mesoderm development; peptidyl-tyrosine phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; regulation of cell proliferation; regulation of gene expression; regulation of lateral mesodermal cell fate specification; regulation of phosphorus metabolic process; regulation of sensory perception of pain; salivary gland morphogenesis; sensory perception of sound; stem cell maintenance; ureteric bud development; vacuolar phosphate transport