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HTATIP2 Blocking Peptide | HTATIP2 (HGNC:16637) blocking peptide

HTATIP2 Antibody (N-term) Blocking Peptide

Gene Names
HTATIP2; CC3; TIP30; SDR44U1
Synonyms
HTATIP2; HTATIP2 Antibody (N-term) Blocking Peptide; Oxidoreductase HTATIP2; 111-; 30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2; HTATIP2 (HGNC:16637) blocking peptide
Ordering
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
242
Cellular Location
Cytoplasm. Nucleus envelope
Tissue Location
Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for HTATIP2 (HGNC:16637) blocking peptide
Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
30,131 Da
NCBI Official Full Name
Oxidoreductase HTATIP2
NCBI Official Synonym Full Names
HIV-1 Tat interactive protein 2
NCBI Official Symbol
HTATIP2
NCBI Official Synonym Symbols
CC3; TIP30; SDR44U1
NCBI Protein Information
oxidoreductase HTATIP2
UniProt Protein Name
Oxidoreductase HTATIP2
UniProt Gene Name
HTATIP2
UniProt Entry Name
HTAI2_HUMAN

Uniprot Description

HTATIP2: Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear envelope; Oxidoreductase; Transcription factor; Tumor suppressor; EC 1.1.1.-; Apoptosis

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: cytoplasm; membrane; nuclear envelope; nucleoplasm; nucleus

Molecular Function: protein binding; transcription coactivator activity

Biological Process: negative regulation of apoptosis; nuclear import; regulation of angiogenesis; regulation of transcription from RNA polymerase II promoter

Research Articles on HTATIP2 (HGNC:16637)

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Product Notes

The HTATIP2 (HGNC:16637) htatip2 (Catalog #AAA9221078) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HTATIP2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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