Rabbit anti-Human AIP Polyclonal Antibody | anti-AIP antibody

AIP, CT (AIP, XAP2, AH receptor-interacting protein, Aryl-hydrocarbon receptor-interacting protein, HBV X-associated protein 2, Immunophilin homolog ARA9) (Azide free) (HRP)

Cat. Num. AAA6272447

• Gene Names: AIP; ARA9; XAP2; XAP-2; FKBP16; FKBP37; SMTPHN
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: AIP; Polyclonal Antibody; CT (AIP; XAP2; AH receptor-interacting protein; Aryl-hydrocarbon receptor-interacting protein; HBV X-associated protein 2; Immunophilin homolog ARA9) (Azide free) (HRP); Immunophilin homolog ARA9; anti-AIP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-AIP antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:10-50; ELISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: AIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-321 amino acids from the C-terminal region of human AIP.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(AIP Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the AIP antibody detected the AIP protein (arrow).)

Immunohistochemistry (IHC)

(AIP Antibody (C-term) (AP14600b)immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AIP Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-AIP antibody

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus.

Product Categories/Family for anti-AIP antibody

Antibodies; Receptors

References

Daly, A.F., et al. J. Clin. Endocrinol. Metab. 95 (11), E373-E383 (2010): Stratakis, C.A., et al. Clin. Genet. 78(5):457-463(2010). Occhi, G., et al. Eur. J. Endocrinol. 163(3):369-376(2010). Igreja, S., et al. Hum. Mutat. 31(8):950-960(2010). Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 201860300
• NCBI GeneID: 9049
• NCBI Accession #: NP_003968.2
• NCBI GenBank Nucleotide #: NM_003977.2
• UniProt Accession #: O00170; Q2M3Q2; Q99606; A0SZW3; A0SZW4; A0SZW5; A0SZW6
• Molecular Weight: 37,636 Da
• NCBI Official Full Name: AH receptor-interacting protein
• NCBI Official Synonym Full Names: aryl hydrocarbon receptor interacting protein
• NCBI Official Symbol: AIP
• NCBI Official Synonym Symbols: ARA9; XAP2; XAP-2; FKBP16; FKBP37; SMTPHN
• NCBI Protein Information: AH receptor-interacting protein; immunophilin homolog ARA9; HBV X-associated protein 2
• UniProt Protein Name: AH receptor-interacting protein
• Protein Family: AH receptor-interacting protein
• UniProt Gene Name: AIP
• UniProt Synonym Gene Names: XAP2; AIP; XAP-2
• UniProt Entry Name: AIP_HUMAN

NCBI Description

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Uniprot Description

AIP: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA); also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma. Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA); also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA); also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; signal transducer activity; transcription coactivator activity; unfolded protein binding; transcription factor binding

Biological Process: protein maturation via protein folding; xenobiotic metabolic process; signal transduction; negative regulation of cyclic-nucleotide phosphodiesterase activity; protein targeting to mitochondrion

Disease: Pituitary Adenoma, Prolactin-secreting; Pituitary Adenoma, Acth-secreting; Pituitary Adenoma, Growth Hormone-secreting