RBM39 blocking peptide

RBM39 Antibody (N-term) Blocking peptide

• Gene Names: RBM39; HCC1; CAPER; RNPC2; FSAP59; CAPERalpha
• Synonyms: RBM39; RBM39 Antibody (N-term) Blocking peptide; RNA-binding protein 39; CAPER alpha; Hepatocellular carcinoma protein 1; RNA-binding motif protein 39; RNA-binding region-containing protein 2; Splicing factor HCC1; HCC1; RNPC2; RBM39 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of RBM39. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 530

• Cellular Location: Nucleus speckle. Note: Concentrated in nuclear speckles. Colocalizes with the core spliceosomal snRNP proteins
• Tissue Location: Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain. Expressed at intermediate level in kidney, liver and heart
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RBM39 blocking peptide

Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process.

NCBI and Uniprot Product Information

• NCBI GI #: 28201880
• NCBI GeneID: 9584
• UniProt Accession #: Q14498; Q14499; A2RRD3; A5D8W2; B0BLV3; E1P5S0; E1P5S1
• Molecular Weight: 57,090 Da
• NCBI Official Full Name: RNA-binding protein 39
• NCBI Official Synonym Full Names: RNA binding motif protein 39
• NCBI Official Symbol: RBM39
• NCBI Official Synonym Symbols: HCC1; CAPER; RNPC2; FSAP59; CAPERalpha
• NCBI Protein Information: RNA-binding protein 39
• UniProt Protein Name: RNA-binding protein 39
• Protein Family: RNA-binding protein
• UniProt Gene Name: RBM39
• UniProt Synonym Gene Names: HCC1; RNPC2
• UniProt Entry Name: RBM39_HUMAN

NCBI Description

This gene encodes a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Aug 2011]

Uniprot Description

RNPC2: Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1. May be involved in pre-mRNA splicing process. Belongs to the splicing factor SR family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Spliceosome; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: microtubule cytoskeleton; microtubule organizing center; nucleoplasm

Molecular Function: protein binding

Biological Process: RNA processing