NAPSA blocking peptide

NAPSA Antibody (C-term) Blocking peptide

• Gene Names: NAPSA; KAP; Kdap; NAP1; NAPA; SNAPA
• Synonyms: NAPSA; NAPSA Antibody (C-term) Blocking peptide; Napsin-A; 3423-; Aspartyl protease 4; ASP4; Asp 4; Napsin-1; TA01/TA02; NAP1; NAPA; NAPSA blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of NAPSA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 420

• Cellular Location: Secreted.
• Tissue Location: Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NAPSA blocking peptide

May be involved in processing of pneumocyte surfactant precursors.

NCBI and Uniprot Product Information

• NCBI GI #: 6225749
• NCBI GeneID: 9476
• UniProt Accession #: O96009; Q8WWD9
• Molecular Weight: 45,387 Da
• NCBI Official Full Name: Napsin-A
• NCBI Official Synonym Full Names: napsin A aspartic peptidase
• NCBI Official Symbol: NAPSA
• NCBI Official Synonym Symbols: KAP; Kdap; NAP1; NAPA; SNAPA
• NCBI Protein Information: napsin-A
• UniProt Protein Name: Napsin-A
• Protein Family: Napsin
• UniProt Gene Name: NAPSA
• UniProt Synonym Gene Names: NAP1; NAPA; ASP4; Asp 4
• UniProt Entry Name: NAPSA_HUMAN

NCBI Description

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]

Uniprot Description

NAPSA: May be involved in processing of pneumocyte surfactant precursors. Belongs to the peptidase A1 family.

Protein type: Protease; EC 3.4.23.-; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular space; lysosome

Molecular Function: aspartic-type endopeptidase activity; endopeptidase activity; peptidase activity

Biological Process: cellular protein metabolic process; membrane protein proteolysis; protein catabolic process; surfactant homeostasis