Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 46475(CEP290 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200))
Rabbit anti-Human CEP290 Polyclonal Antibody | anti-CEP290 antibody
CEP290 Antibody
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 46475(CEP290 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 46475(CEP290 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 46475(CEP290 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 46475(CEP290 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer. [provided by RefSeq, Jul 2008]
Uniprot Description
Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973).
Research Articles on CEP290
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Product Notes
The CEP290 cep290 (Catalog #AAA9429622) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CEP290 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CEP290 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1: 25-100. Researchers should empirically determine the suitability of the CEP290 cep290 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CEP290, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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