DCTN4 blocking peptide

DCTN4 Antibody (N-term) Blocking peptide

• Gene Names: DCTN4; P62; DYN4
• Synonyms: DCTN4; DCTN4 Antibody (N-term) Blocking peptide; Dynactin subunit 4; Dyn4; Dynactin subunit p62; DCTN4 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of DCTN4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 460

• Cellular Location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note: In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DCTN4 blocking peptide

Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

NCBI and Uniprot Product Information

• NCBI GI #: 62900106
• NCBI GeneID: 51164
• UniProt Accession #: Q9UJW0; Q8TAN8; B3KWW0; D3DQH0; E5RGT5
• Molecular Weight: 53,152 Da
• NCBI Official Full Name: Dynactin subunit 4
• NCBI Official Synonym Full Names: dynactin subunit 4
• NCBI Official Symbol: DCTN4
• NCBI Official Synonym Symbols: P62; DYN4
• NCBI Protein Information: dynactin subunit 4
• UniProt Protein Name: Dynactin subunit 4
• Protein Family: Dynactin
• UniProt Gene Name: DCTN4
• UniProt Synonym Gene Names: Dyn4
• UniProt Entry Name: DCTN4_HUMAN

Uniprot Description

dynactin 4: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. Belongs to the dynactin subunit 4 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor; Microtubule-binding

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: centrosome; cytoplasm; cytoplasmic dynein complex; cytosol; dynactin complex; nucleus

Molecular Function: protein binding; protein N-terminus binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; ER to Golgi vesicle-mediated transport; nuclear migration