PDCL3 blocking peptide

PDCL3 Antibody (N-term) Blocking peptide

• Gene Names: PDCL3; VIAF; PHLP3; VIAF1; HTPHLP; PHLP2A
• Synonyms: PDCL3; PDCL3 Antibody (N-term) Blocking peptide; Phosducin-like protein 3; HTPHLP; PhPL3; Viral IAP-associated factor 1; VIAF-1; PhLP2A; VIAF1; PDCL3 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of PDCL3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 239

• Cellular Location: Cytoplasm.
• Tissue Location: Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PDCL3 blocking peptide

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination.

NCBI and Uniprot Product Information

• NCBI GI #: 50401164
• NCBI GeneID: 79031
• UniProt Accession #: Q9H2J4; Q53S68; B2RA00
• Molecular Weight: 27,614 Da
• NCBI Official Full Name: Phosducin-like protein 3
• NCBI Official Synonym Full Names: phosducin like 3
• NCBI Official Symbol: PDCL3
• NCBI Official Synonym Symbols: VIAF; PHLP3; VIAF1; HTPHLP; PHLP2A
• NCBI Protein Information: phosducin-like protein 3
• UniProt Protein Name: Phosducin-like protein 3
• Protein Family: Phosducin-like protein
• UniProt Gene Name: PDCL3
• UniProt Synonym Gene Names: PhLP2A; VIAF1; VIAF-1
• UniProt Entry Name: PDCL3_HUMAN

NCBI Description

This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

Uniprot Description

PDCL3: Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination. Belongs to the phosducin family.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 2q11.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; queuine tRNA-ribosyltransferase activity

Biological Process: positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; queuosine biosynthetic process; regulation of peptidyl-tyrosine phosphorylation