MEPCE blocking peptide

MEPCE Antibody (Center) Blocking Peptide

• Gene Names: MEPCE; BCDIN3
• Synonyms: MEPCE; MEPCE Antibody (Center) Blocking Peptide; 7SK snRNA methylphosphate capping enzyme; MePCE; 211-; Bicoid-interacting protein 3 homolog; Bin3 homolog; BCDIN3; MEPCE blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of MEPCE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 689

• Tissue Location: Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MEPCE blocking peptide

S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.

NCBI and Uniprot Product Information

• NCBI GI #: 74758999
• NCBI GeneID: 56257
• UniProt Accession #: Q7L2J0; Q9NPD4; B3KP86; D6W5V7
• Molecular Weight: 24,950 Da
• NCBI Official Full Name: 7SK snRNA methylphosphate capping enzyme
• NCBI Official Synonym Full Names: methylphosphate capping enzyme
• NCBI Official Symbol: MEPCE
• NCBI Official Synonym Symbols: BCDIN3
• NCBI Protein Information: 7SK snRNA methylphosphate capping enzyme
• UniProt Protein Name: 7SK snRNA methylphosphate capping enzyme
• Protein Family: 7SK snRNA methylphosphate capping enzyme
• UniProt Gene Name: MEPCE
• UniProt Synonym Gene Names: BCDIN3; MePCE; Bin3 homolog
• UniProt Entry Name: MEPCE_HUMAN

Uniprot Description

BCDIN3: a CDK9-associated enzyme that forms the distinctive gamma-methylphosphate cap structure of 7SK, a noncoding RNA that regulates CDK9 activity. An adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to its stabilization. Component of the 7SK snRNP complex that contains P-TEFb (composed of CDK9 and CCNT1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues. Contains a Bin3 domain found in a number of protein methyltransferases that modify RNA-binding proteins.

Protein type: Transcription regulation; Methyltransferase; RNA processing; EC 2.1.1.; EC 2.1.1.-

Chromosomal Location of Human Ortholog: 7q22.1

Molecular Function: RNA methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity

Biological Process: RNA methylation; snRNA metabolic process; snRNA modification