STAMBP blocking peptide

STAMBP Antibody (C-term) Blocking peptide

• Gene Names: STAMBP; AMSH; MICCAP
• Synonyms: STAMBP; STAMBP Antibody (C-term) Blocking peptide; STAM-binding protein; 3419-; Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase; AMSH; STAMBP blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 424

• Cellular Location: Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome
• Tissue Location: Ubiquitously expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for STAMBP blocking peptide

Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.

NCBI and Uniprot Product Information

• NCBI GI #: 71153538
• NCBI GeneID: 10617
• UniProt Accession #: O95630; Q3MJE7; B5M0B6; D6W5H7
• Molecular Weight: 39,596 Da
• NCBI Official Full Name: STAM-binding protein
• NCBI Official Synonym Full Names: STAM binding protein
• NCBI Official Symbol: STAMBP
• NCBI Official Synonym Symbols: AMSH; MICCAP
• NCBI Protein Information: STAM-binding protein
• UniProt Protein Name: STAM-binding protein
• Protein Family: STAM-binding protein
• UniProt Gene Name: STAMBP
• UniProt Synonym Gene Names: AMSH
• UniProt Entry Name: STABP_HUMAN

NCBI Description

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

AMSH: an adaptor protein involved in cytokine signal transduction the JAK-STAT cascade. Binds to the SH3 domain of the signal-transducing adaptor molecule STAM (signal transducing adaptor molecule). May play a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression.

Protein type: EC 3.1.2.15; Protease; Ubiquitin-specific protease; EC 3.4.19.-

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: cleavage furrow; cytoplasm; nucleoplasm; nucleus; plasma membrane

Molecular Function: protein binding; protein domain specific binding; ubiquitin-specific protease activity

Biological Process: cytokinesis after mitosis; JAK-STAT cascade; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of Ras protein signal transduction; positive regulation of cell proliferation; protein deubiquitination

Disease: Microcephaly-capillary Malformation Syndrome