KCNJ4 blocking peptide

KCNJ4 Antibody (N-term) Blocking peptide

• Gene Names: KCNJ4; HIR; HRK1; IRK3; HIRK2; IRK-3; Kir2.3
• Synonyms: KCNJ4; KCNJ4 Antibody (N-term) Blocking peptide; Inward rectifier potassium channel 4; HIRK2; HRK1; Hippocampal inward rectifier; HIR; Inward rectifier K(+) channel Kir23; IRK-3; Potassium channel; inwardly rectifying subfamily J member 4; IRK3; KCNJ4 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 445

• Cellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Note: TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization
• Tissue Location: Heart, skeletal muscle, and several different brain regions including the hippocampus
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for KCNJ4 blocking peptide

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 1352483
• NCBI GeneID: 3761
• UniProt Accession #: P48050; Q14D44
• Molecular Weight: 49,500 Da
• NCBI Official Full Name: Inward rectifier potassium channel 4
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily J member 4
• NCBI Official Symbol: KCNJ4
• NCBI Official Synonym Symbols: HIR; HRK1; IRK3; HIRK2; IRK-3; Kir2.3
• NCBI Protein Information: inward rectifier potassium channel 4
• UniProt Protein Name: Inward rectifier potassium channel 4
• Protein Family: Inward rectifier potassium channel
• UniProt Gene Name: KCNJ4
• UniProt Synonym Gene Names: IRK3; HIR; IRK-3
• UniProt Entry Name: KCNJ4_HUMAN

NCBI Description

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

HIR: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily.

Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: basolateral plasma membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function: G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; PDZ domain binding; protein binding

Biological Process: potassium ion import; potassium ion transport