Rabbit anti-Human, Rat KCNJ4 Polyclonal Antibody | anti-KCNJ4 antibody

KCNJ4 Antibody

Cat. Num. AAA7043901

• Gene Names: KCNJ4; HIR; HRK1; IRK3; HIRK2; IRK-3; Kir2.3
• Reactivity: Human, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: KCNJ4; Polyclonal Antibody; KCNJ4 Antibody; Inward rectifier potassium channel 4; HIRK2; HRK1; Hippocampal inward rectifier; HIR; Inward rectifier K(+) channel Kir2.3; IRK-3; Potassium channel; inwardly rectifying subfamily J member 4; IRK3; anti-KCNJ4 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 445

• Applicable Applications for anti-KCNJ4 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Species: Human
• Immunogen: Recombinant human Inward rectifier potassium channel 4 protein (C-130AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23632
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: KCNJ4 antibody at 2.04ug/mlLane 1: Rat heart tissueLane 2: A549 whole cell lysateLane 3: Hela whole cell lysateLane 4: 293T whole cell lysateLane 5: HepG-2 whole cell lysateLane 6: Jurkat whole cell lysateLane 7: MCF7 whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 50 kDaObserved band size: 50 kDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human skeletal muscle tissue MBS7043901 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human heart tissue MBS7043901 at dilution 1:100)

Related Product Information for anti-KCNJ4 antibody

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 4826798
• NCBI GeneID: 3761
• NCBI Accession #: NP_004972.1
• NCBI GenBank Nucleotide #: NM_004981.1
• UniProt Accession #: P48050; Q14D44
• Molecular Weight: 49,500 Da
• NCBI Official Full Name: inward rectifier potassium channel 4
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily J member 4
• NCBI Official Symbol: KCNJ4
• NCBI Official Synonym Symbols: HIR; HRK1; IRK3; HIRK2; IRK-3; Kir2.3
• NCBI Protein Information: inward rectifier potassium channel 4
• UniProt Protein Name: Inward rectifier potassium channel 4
• Protein Family: Inward rectifier potassium channel
• UniProt Gene Name: KCNJ4
• UniProt Synonym Gene Names: IRK3; HIR; IRK-3
• UniProt Entry Name: KCNJ4_HUMAN

NCBI Description

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

HIR: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: basolateral plasma membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function: G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; PDZ domain binding; protein binding

Biological Process: potassium ion import; potassium ion transport