CLEC2A blocking peptide

CLEC2A Antibody (Center) Blocking peptide

• Gene Names: CLEC2A; KACL; PILAR; UNQ5792; INPE5792
• Synonyms: CLEC2A; CLEC2A Antibody (Center) Blocking peptide; C-type lectin domain family 2 member A; Keratinocyte-associated C-type lectin; KACL; Proliferation-induced lymphocyte-associated receptor; PILAR; CLEC2A blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 174

• Cellular Location: Cell membrane; Single-pass type II membrane protein
• Tissue Location: Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CLEC2A blocking peptide

Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.

NCBI and Uniprot Product Information

• NCBI GI #: 212276429
• NCBI GeneID: 387836
• UniProt Accession #: Q6UVW9; A5Y4G5; A9QKS2; A9QKS3
• Molecular Weight: 18,576 Da
• NCBI Official Full Name: C-type lectin domain family 2 member A
• NCBI Official Synonym Full Names: C-type lectin domain family 2 member A
• NCBI Official Symbol: CLEC2A
• NCBI Official Synonym Symbols: KACL; PILAR; UNQ5792; INPE5792
• NCBI Protein Information: C-type lectin domain family 2 member A
• UniProt Protein Name: C-type lectin domain family 2 member A
• Protein Family: C-type lectin domain family
• UniProt Gene Name: CLEC2A
• UniProt Synonym Gene Names: KACL; KACL; PILAR
• UniProt Entry Name: CLC2A_HUMAN

NCBI Description

CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008]

Uniprot Description

CLEC2A: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Molecular Function: protein binding; protein homodimerization activity

Biological Process: natural killer cell mediated cytotoxicity