BHLHE40 blocking peptide

BHLHE40 Antibody (N-term) Blocking Peptide

• Gene Names: BHLHE40; DEC1; HLHB2; BHLHB2; STRA13; Stra14; SHARP-2
• Synonyms: BHLHE40; BHLHE40 Antibody (N-term) Blocking Peptide; Class E basic helix-loop-helix protein 40; bHLHe40; Class B basic helix-loop-helix protein 2; bHLHb2; Differentially expressed in chondrocytes protein 1; DEC1; Enhancer-of-split and hairy-related protein 2; SHARP-2; Stimulated by retinoic acid gene 13 protein; BHLHB2; SHARP2; STRA13; BHLHE40 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 412

• Cellular Location: Cytoplasm. Nucleus. Nucleus, nucleolus. Note: Predominantly localized in the nucleus
• Tissue Location: Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for BHLHE40 blocking peptide

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 4503299
• NCBI GeneID: 8553
• NCBI Accession #: NP_003661.1
• NCBI GenBank Nucleotide #: NM_003670.2
• UniProt Accession #: O14503; Q96TD3
• Molecular Weight: 45,510 Da
• NCBI Official Full Name: class E basic helix-loop-helix protein 40
• NCBI Official Synonym Full Names: basic helix-loop-helix family member e40
• NCBI Official Symbol: BHLHE40
• NCBI Official Synonym Symbols: DEC1; HLHB2; BHLHB2; STRA13; Stra14; SHARP-2
• NCBI Protein Information: class E basic helix-loop-helix protein 40
• UniProt Protein Name: Class E basic helix-loop-helix protein 40
• Protein Family: Class E basic helix-loop-helix protein
• UniProt Gene Name: BHLHE40
• UniProt Synonym Gene Names: BHLHB2; DEC1; SHARP2; STRA13; bHLHe40; bHLHb2; DEC1; SHARP-2
• UniProt Entry Name: BHE40_HUMAN

NCBI Description

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]

Uniprot Description

BHLHB2: May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway.

Protein type: Nucleolus; Transcription regulation

Chromosomal Location of Human Ortholog: 3p26

Cellular Component: Golgi apparatus; nucleolus; nucleus

Molecular Function: bHLH transcription factor binding; MRF binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription corepressor activity

Biological Process: circadian regulation of gene expression; entrainment of circadian clock by photoperiod; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent